This study compared the efficacy and safety of low doses of rosuvastatin (10 mg) and atorvastatin (20 mg) in high-risk patients with hypercholesterolemia. Treatment of hyperlipidemia is helpful in both primary and secondary prevention of coronary heart disease and stroke. van Himbergen TM(1), Matthan NR, Resteghini NA, Otokozawa S, Ai M, Stein EA, Jones PH, Schaefer EJ. Many patients at high risk of cardiovascular disease do not achieve recommended low-density lipoprotein cholesterol (LDL-C) goals. The mean dose of atorvastatin and rosuvastatin were 50.8 (24.7) mg/day and 21.4 (9.6) mg/day, respectively, corresponding to a medium dose of a high potency statin and they were equivalent with respect to their lipid-lowering efficacy. Table 4. Background . Aim . Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers. LDL Cholesterol Changes with 10-mg Daily Statin Dose a; LDL Cholesterol Value Rosuvastatin (n = 186) Atorvastatin (n = 159) p b; Mean ± S.D. lovastatin pravastatin simvastatin % ldl reduction (mevacor*) (pravachol*) (zocor*) lescol lipitor crestor vytorin 25-32% 20 mg 20mg 10mg 40mg - - - 31-39% 40mg 40mg 20mg 80mg 10mg - - 37-45% 80mg 80mg 40mg - 20mg 5mg 10/10 Crestor vs Lipitor comparison. RESULTS: Rosuvastatin reduced LDL-C levels significantly more than atorvastatin during the fixed-dose and titration periods (p < 0.0001). At 6 weeks, across-dose analyses showed that rosuvastatin 10 to 80 mg reduced LDL cholesterol by a mean of 8.2% more than atorvastatin 10 to 80 mg, 26% more than pravastatin 10 to 40 mg, and 12% to 18% more than simvastatin 10 to 80 mg (all p <0.001). The Use of Rosuvastatin versus Atorvastatin iN type 2 diabetes mellitUS (URANUS) study compared rosuvastatin with atorvastatin for the reduction of low-density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes. Methodology . Significantly more patients reached the 1998 LDL-C goal with rosuvastatin 10 mg compared with atorvastatin 10 mg at 4 weeks (81% vs 65%, p < 0.001). To compare lipid-lowering efficacy of rosuvastatin with atorvastatin. There is very little difference in the medicinal properties of statins Crestor (rosuvastatin) and Lipitor (atorvastatin).
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