statins and depression 2018

Epub 2006 Nov 13. Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions. Alghamdi J, Matou-Nasri S, Alghamdi F, Alghamdi S, Alfadhel M, Padmanabhan S. Int J Neuropsychopharmacol. COVID-19 is an emerging, rapidly evolving situation.  |  Köhler-Forsberg O, Gasse C, Berk M, Østergaard SD. Depression and Statin Drug Use From thousands of reports I have seen a strong association between statin drug use and affective disorders of all kinds. Front Psychiatry. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Clipboard, Search History, and several other advanced features are temporarily unavailable. Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study. USA.gov. CNS Drugs. This article reviews i) cholesterol function in the brain, ii) how low cholesterol can cause depression, iii) a brief introduction of the serotonin system and how low cholesterol can disturb it, iv) neurosteroids and how they may lead to depression, and v) some direct evidence that statins can cause depression as well as contradicting evidence. Nature Reviews Cardiology. Pleiotropic effects of statins: evidence against benefits beyond LDL-cholesterol lowering. Statin medications also reduce inflammation. We know that cholesterol plays an important role in the serotonin system, so statins used to lower cholesterol may lead to the occurrence of depression. Although this article stresses depression and its most extreme form, suicide, other affective manifestations include hostility, aggressiveness, rage, combativeness, accident proneness and special proneness for use of addictive substances. Associations between statin use and suicidality, depression, anxiety, and seizures: a Swedish total-population cohort study.  |  While counterintuitive, antidepressants can have the inverse effect of increasing depression symptoms rather than reducing them. Lieberman A, Lyons K, Levine J, Myerburg R. Parkinsonism Relat Disord. Renshaw PF, Parsegian A, Yang CK, Novero A, Yoon SJ, Lyoo IK, Cohen BM, Carlezon WA Jr. Pharmacol Biochem Behav. Conclusions: These results suggest that the association between statin treatment and antidepressant use is unspecific (equivalent association between statins and most other drugs) and that the association between statin use and depression diagnoses is mediated by residual confounding, bias or by downstream effects of the statin prescription (seeing a physician more often). Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress. 2005 Mar;11(2):81-4. doi: 10.1016/j.parkreldis.2004.07.012. 2010;10 Suppl 1:10-7. doi: 10.2165/1158822-S0-000000000-00000. The effects of statins on mood: a review of the literature. HHS This site needs JavaScript to work properly. 2019 Oct 16;9(10):e030272. However, the benefits of lowering total and LDL cholesterol have been demonstrated extensively, particularly in individuals with heart disease or at high risk of heart disease or strokes. 2019;26:e000. Med Hypotheses. 2019 Jul;33(7):685-694. doi: 10.1007/s40263-019-00633-3.  |  Statins have been widely used in clinical practice; however, the association between statin use and depression is complex as research findings have been mixed. CNS Drugs. Get the latest research from NIH: https://www.nih.gov/coronavirus. 2018 Dec 1;21(12):1067-1075. doi: 10.1093/ijnp/pyy060. NLM 2019 Apr 9;10:200. doi: 10.3389/fpsyt.2019.00200. Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M; ASPREE Investigator Group. Schang L, Koller D, Franke S, Sundmacher L. BMJ Open. Introduction: HHS Epub 2012 Jul 7. This site needs JavaScript to work properly. © Copyright 2018 Physicians Postgraduate Press, Inc. NLM Expert Opin Pharmacother. USA.gov. CNS Drugs. Preparation of this article included an extensive literature search of statins and depression using PubMed from 1972 to 2012. Since the pathophysiology of depression involves inflammation, statins could have a role in the treatment of mood disorders and might become a pharmacotherapy option for patients experiencing depression. Zuzarte P, Duong A, Figueira ML, Costa-Vitali A, Scola G. Curr Drug Metab. Alonso R, et al. Statins may enhance the proteolytic cleavage of proBDNF: implications for the treatment of depression. Introduction: Statins have been widely used in clinical practice; however, the association between statin use and depression is complex as research findings have been mixed. This article shows that statins could lead to depression by lowering cholesterol and that we should draw attention to this in clinical application, especially for patients complicated with depressive symptoms or low serum cholesterol levels. 2017 May;31(5):335-343. doi: 10.1007/s40263-017-0422-3. There is evidence suggesting an antidepressant effect when statins are adjunctively co-prescribed with antidepressant medicines. Statins provide protection against coronary and cerebrovascular diseases by decreasing cholesterol synthesis in the liver. Depression is a common malady associated with numerous chronic medical conditions such as coronary artery disease, hypertension, and diabetes.  |  Expert opinion: The safety and effectiveness of statins as treatment for HIV-dyslipidemia: the evidence so far and the future challenges. Yet, new guidelines and research suggest that statins’ benefits do not apply to everyone. doi: 10.1136/bmjopen-2019-030272. NIH Kelly RR, McDonald LT, Jensen NR, Sidles SJ, LaRue AC. Epub 2014 Jun 12. 2007;68(6):1296-9. doi: 10.1016/j.mehy.2006.09.043. Please enable it to take advantage of the complete set of features! Risk of Neuropsychiatric Adverse Effects of Lipid-Lowering Drugs: A Mendelian Randomization Study. Areas covered: Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Pharmacol Biochem Behav. Clipboard, Search History, and several other advanced features are temporarily unavailable. Get the latest public health information from CDC: https://www.coronavirus.gov. COVID-19 is an emerging, rapidly evolving situation. 2017 May;31(5):335-343. doi: 10.1007/s40263-017-0422-3. For example, people with depression may have low cholesterol levels, but it has not been proved that lowering cholesterol with statin therapy causes depression. Adverse effects of statin therapy: Perception vs. the evidence — focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract. NIH 2014 Sep;124:174-9. doi: 10.1016/j.pbb.2014.06.006. Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats.  |  Epub 2013 Sep 19. Mach F, et al. Statins provide protection against coronary and cerebrovascular diseases by decreasing cholesterol synthesis in the liver. Journal of Atherosclerosis and Thrombosis. Eur J Cardiovasc Nurs. 2020 Nov;7(11):982-990. doi: 10.1016/S2215-0366(20)30311-4. 2018;19(8):674-687. doi: 10.2174/1389200219666180305143501. Diagnosis and management of statin intolerance. 2009 Mar;92(1):88-92. doi: 10.1016/j.pbb.2008.10.017. Of the individual statins, simvastatin, by far the most widely used agent, was associated with a 7% reduction in the risk of developing depression, whereas atorvastatin was associated with an 11% increase in the risk of developing depression. Get the latest public health information from CDC: https://www.coronavirus.gov. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Statin therapy continues to help men lower their cholesterol levels, which can reduce their risk for heart attack or stroke. Molero Y, Cipriani A, Larsson H, Lichtenstein P, D'Onofrio BM, Fazel S. Lancet Psychiatry. 2012 Mar;11(1):85-96. doi: 10.1016/j.ejcnurse.2010.08.008. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Since antidepressants work by changing neurotransmitter levels in the brain, it's possible for the chemicals to become imbalanced, which can lead to more severe mood symptoms, including thoughts of suicide. Current Therapeutic Approaches for Targeting Inflammation in Depression and Cardiovascular Disease. Expert Opin Pharmacother. Please enable it to take advantage of the complete set of features! eCollection 2019.  |  Comment on: the relationship between statins and depression: a review of the literature. 2018;12:757. Get the latest research from NIH: https://www.nih.gov/coronavirus. Am J Cardiovasc Drugs. Epub 2008 Nov 5. We know that cholesterol plays an important role in the serotonin system, so statins used to lower cholesterol may lead to the occurrence of depression.

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